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Notably, while total FOXO4 protein levels remained consistent between young and elderly men, a striking age-dependent shift in its subcellular localization was observed: FOXO4 predominantly resided in the cytoplasm in young Leydig cells but translocated to the nucleus in aged cells

(2023): Cardiovascular Health Benefits A 2023 study by Figueroa and colleagues examined the combination's effects on vascular function and blood pressure in postmenopausal women